When the brothers came to Red Lodge, Montana to investigate a series of grisly murders in the area, they settled in Adobe Court Motel in Room No. 4.
Bored at the bar for the "celebration", Sam returned to the motel room and he was attacked and abducted by the vampires but was later returned safe and sound.
Dean and the obsessed vampire hunter, Gordon, came there after their stint at the bar. When Sam came back and asked Dean to step out with him, Gordon eavesdropped on them and then took off with the car keys to go kill the vampires.