When Deanna met her future grandson Dean Winchester, she invited him for dinner despite not knowing his connection to her family.
Later, Deanna found Samuel possessed by Azazel and taunting an immobilized Dean; she tried to sneak up behind them for a surprise attack but Azazel noticed her presence when she cried out in response to him fatally wounding his host - her husband. She rushed to grab The Colt but Azazel grabbed her and snapped her neck before she could, killing her.
- Deanna was named for Supernatural creator Eric Kripke's wife.
- She is apparently the namesake of her oldest grandson, Dean Winchester.
- She never met her youngest grandson, Sam Winchester.