Jefferson Rooney is the President of the United States.
A spiritual man, Rooney agrees to possession by Lucifer in exchange for Lucifer teaching him how to make America a more spiritual place. In order to pass as Rooney, Lucifer communicates with him briefly in his mind while using Rooney's influence and position to send the Secret Service after the Winchesters. Lucifer also has sex with Kelly Kline, Rooney's mistress while using him as a vessel and conceives a Nephilim.
Lucifer is ultimately exorcised from Rooney by Sam Winchester with a hyperbolic pulse generator. Castiel checks on Rooney and finds that he has survived Lucifer's possession of him. Castiel erases Rooney's memory of the possession and he wakes up a few minutes later. However, the Secret Service discover the Winchesters checking on him and believe they had attempted to assassinate Rooney. As a result, the Winchesters are arrested for attempting to assassinate the President of the United States.
A conversation between Rick and Camp later on reveals that Jefferson has no recollection of the past three days and they assume he may have been drugged. A lab is running a tox screen just to be sure.
- In "LOTUS", the President of the United States is revealed to be Jefferson Rooney. However in "Time After Time", Dean tells Eliot Ness that in 2012, the president was a black guy. Furthermore, Dean mentions Barack Obama by name in "Paper Moon". Jefferson Rooney is presumably Obama's successor.
- Obama's real-life successor is Donald Trump. This makes Jefferson the only fictional president in the series.
- Rooney is also the only president to make a physical appearance.
- Rooney is only one of three vessels to survive Lucifer possessing them, the other two being Sam Winchester and Castiel. Presumably, Lucifer was expelled from Rooney before his body began to deteriorate.