- Jared Padalecki as Sam Winchester
- Jensen Ackles as Dean Winchester
- Mark Pellegrino as Lucifer
- Misha Collins as Castiel
- Alexander Calvert as Jack
- Rob Raco as Clark
- Carlena Britch as Miriam
Featured Supernatural BeingsEdit
- The episode picks up right after the events of All Along the Watchtower.
- The alternate universe was previously seen in All Along the Watchtower.
- This is the first season premiere to not feature Crowley since I Think I'm Gonna Like It Here in Season 9.
- This is the third season premiere to feature Lucifer and an Archangel with Sympathy for the Devil in Season 5 and Meet the New Boss in Season 7 being the first two.
- This is the first episode of the series to feature the same alternate universe.
- This is the first episode in which Alexander Calvert is credited as a regular. He was credited as a guest star in his previous appearence in season 12 finale.