Pellegrino has appeared in episodes of The Beast, NYPD Blue, Without a Trace, Dexter, Grimm, Prison Break, CSI: Crime Scene Investigation, The Mentalist, Burn Notice, and The Number 23.
He is best known for his role in the Americanized version of the UK supernatural drama Being Human as the leader of the Boston vampire group Bishop. Other major role is his portrayal of Jacob in Lost.
One of his most recent television roles was Dr. Jedikiah Price, on the The Tomorrow People, which was ultimately canceled. He later appeared on Quantico as Clayton Haas.
Mark is married to Tracy Aziz and stepfather of her daughter Tess. Mark is an atheist.
- According to Supernatural creator, Eric Kripke, Mark did not require auditioning for the role of Lucifer.
- Previously, Mark had auditioned for the role of Castiel, but this was given to Misha Collins.
- Mark has not watched Supernatural or any of his other television roles, instead he lets his wife Tracy review them. Recently, Mark stated that he will begin watching them.
- At Vancon 2012, Richard Speight Jr. had gotten Mark drunk which led to him dancing during the convention. Richard is believed to have regretted this decision afterwards.
- Season 5
- Season 7
- Season 11