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She's a Nephilim, an abomination.

Nephilim is a hybrid creature born from the union of an angel and a human. Castiel stated that creating a Nephilim is forbidden; however, Metatron revealed in "Clip Show" that there was one existing on Earth. Metatron viewed this Nephilim as an abomination due to her existence being outlawed.

Characteristics

As stated, Nephilim are the result of sexual reproduction between a human and an occupied angel vessel, the latter giving the offspring angelic properties. Nephilim are only created if their angelic parent has his or her grace during conception, which seems to be the source of what makes a Nephilim. If an angel mates with a human without its grace, the resulting offspring will be completely human. Nephilim have glowing eyes like an angel, although their glow is somewhat dim and grayish in color as opposed to the bright white or bluish-white glow of regular angels. 

Known Nephilims

Powers and Abilities

  • Astral Perception - A Nephilim can perceive the true form of angels without harm.
  • Super Strength - Their angelic ancestry endows Nephilim with enhanced strength sufficient to overpower and even toss common angels around. One was able to throw around a wounded seraph.

Weaknesses

Notes

  • The first part of a spell to expel all angels from Heaven is to "cut out the heart" of a Nephilim. According to Crowley's translation of the spell from the angel tablet, the Nephilim's heart itself is one of the three ingredients.
  • The only Nephilim on Earth, Jane, was at least 20 years old. As Angels didn't typically intertwine on earth during the time of her conception, the only angels present on earth were Reapers, Cherubs, Gabriel, Metatron, and what remains of the Grigori. As the Grigori were responsible for producing the nephilim in lore, it is likely that she was fathered by one of these Angels.
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