Pamela Clayton worked with Dr. Amanda Lee at a medical clinic in Oregon.
When Sam and Dean brought in Mrs. Tanner, she came out and called for Dr. Lee. When she heard about the outbreak of a new virus and how it was taking over the town, she wanted to go find her boyfriend, but was stopped. While examining Mrs. Tanner's blood, she accidentally dropped it and she got infected by the virus. Once Sam was alone, she walked into the room and locked the door. She attacked Sam and cut him and her hand to spread the virus to Sam. Dean managed to break in, and killed her.