Creatures who feeds on souls:
- Crocottas - Crocottas need to feed on human souls for survival.
- Shtrigas - Shtrigas have the ability to feed on a person's spiritus-vitae or life-force (a concept very connected and used interchangeably with the soul).
- Soul Eater - A creature that drags people's souls into their "Nest" to consume them.
- Tzitzimimeh - (tie-in Novels only) their bite consumes the soul of their victims, turning them into zombie that go after other people's souls.
Creatures who absorbs souls in order to increase their power:
- Archangels/Seraphim/Grigori - Higher angels have the ability to absorb souls, an ability that makes them more powerful (Castiel for example was powerful enough to smite Raphael with a snap of his fingers after he absorbed millions of monsters' souls from Purgatory).
- The Darkness - She is able to consume any kind of souls (humans' and demons') and the grace of angels.
- Famine - The Horsemen was able to consume souls.
- Whitman Van Ness (only ghosts) - Whitman was able to "drain" ghosts to gain greater power (destroying the ghosts in the process).