The Natural Order of Things, or The Natural Order for short, is one of, if not the only, governing forces behind the universe. One of its most important roles, is that it is connected to the flow of life and death and assures that people live and die as they should.
- Reapers have a connection to it. They can see a person's whole lifetime and when and how that person will die and when it is time for them to die. The Natural Order is impartial and both good and evil are subject to its power and when it is time to die, a person will and must die.
- Death has a role in his job as Death. He follows the natural order as it dictates the flow of life and death. Death while able to bend or even break the order, didn't like to do so. As they often cause chaos and violations in the world. As he asked Dean when he was Death, "Wrecking the Natural Orders isn't as much when mop up the mess is it?"
- Eve is also aware of the Order and claims to have an "arrangement" between the balance of killing between humans and monsters.
- Atropos, one of the Fates, has a role within the Natural Order. She designs the ways in which people die, and makes sure that events occur according to destiny.
- Mandatory Existence of Light and Dark - God and The Darkness are the most notable pillars of The Order, as they both need each other to exist; otherwise, reality itself would be erased. However, it has been said that if both were to be killed, reality would continue to exist in a new state.
The Natural Order also have places, that fall under its laws. Mostly the spiritual realms where souls go. Reapers are the ones that take humans souls to Heaven, Hell, and possibly monster souls to Purgatory.
- Heaven: The spiritual world where mostly good souls go to.
- Hell: The spiritual world where mostly evil souls go to.
- Purgatory: The spiritual world that souls of monsters go to.
- The Empty: A realm where souls can be sent, but can't be recovered from.
- In Bobby Singer's Guide to Hunting, Eve herself wanted to ensure that her children also follow the Natural Order, even going to extremes as forging the dragon swords to stop her dragons, should they attempt to destroy other beings.
- In the same book, Lethe or Oblivion, a pagan deity, was also shown working for Heaven. Her role was to wipe memories of people who have seen or witnessed something supernatural that they shouldn't have.
- During Dean's time as a demon, he states that his kind are part of The Natural Order and that's how it was set up.
- In situations where the Natural Order is disrupted (e.g.: a person dying before/after their time, or a person being resurrected), the aftermath will last as long as the cause of the disruption exists. As Tessa once mentioned after Dean (during his day as Death) refused to reap a little girl, "chaos and sadness will follow her for the rest of her life" (referring to the girl). According to Death, Sam and Dean, due to their repeated resurrections, "cause disruption on a global scale".